(S,R,S)-AHPC-Me dihydrochloride
HY-42424A
Overview
- SupplierMedChem Express
- Product Name(S,R,S)-AHPC-Me dihydrochloride
- Delivery Days Customer10
- Estimated Purity98.12%
- Molecular FormulaC23H34Cl2N4O3S
- Molecular Weight517.51
- Scientific Description(S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
- SMILESN[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O.Cl.Cl
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200