Overview
- SupplierGeneTex
- Product NameSTAT6 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.27 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A high-throughput pipeline for validation of antibodies. Sikorski K et al., 2018 Nov, Nat MethodsRead more
- Cross-talk between human airway epithelial cells and 3T3-J2 feeder cells involves partial activation of human MET by murine HGF. Hynds RE et al., 2018, PLoS OneRead more
- Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells. Xu YM et al., 2016 Feb 2, OncotargetRead more
- Solitary Fibrous Tumor of Breast with Anaplastic Areas (Malignant Solitary Fibrous Tumor): A Case Report with Review of Literature. Jung MJ et al., 2019 Jun, J Breast CancerRead more
- Support of BCP-ALL-cells by autologous bone marrow Th-cells involves induction of AID expression but not widespread AID off-target mutagenesis. Traxel S et al., 2021 Aug, Cancer Immunol ImmunotherRead more