Tenovin-6 [1011557-82-6]
T1853
Estimated Purity≥98%
Product group Chemicals
Overview
- SupplierLKT Laboratories
- Product NameTenovin-6 [1011557-82-6]
- Delivery Days Customer7
- Estimated Purity≥98%
- FormatDMSO 98 mg/mL (215.55 mM); Water 98 mg/mL warmed (215.55 mM); Ethanol Insoluble
- Scientific DescriptionSIRT1/2 inhibitor, indirect p53 activator.
- Storage Instruction-20°C
- UNSPSC12352200
References
- Ueno T, Endo S, Saito R, et al. The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-Fluorouracil and oxaliplatin in colon cancer cells. Oncol Res. 2014;21(3):155-64. PMID: 24512730. MacCallum SF, Groves MJ, James J, et al. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6. Sci Rep. 2013;3:1275. PMID: 23429453. Lain S, Hollick JJ, Campbell J, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63. PMID: 18455128. Brooks CL, Gu W. p53 Activation: a case against Sir. Cancer Cell. 2008 May;13(5):377-8. PMID: 18455119.