Tozasertib [639089-54-6]
S1048
Product group Chemicals
Overview
- SupplierSelleck Chemicals
- Product NameTozasertib [639089-54-6]
- Delivery Days Customer9
- CertificationResearch Use Only
- Scientific DescriptionTozasertib (VX-680, MK-0457) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosis and autophagy. Phase 2.
- UNSPSC12352200