Overview
- SupplierGeneTex
- Product NameUHRF1 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.97 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A proteomic characterization of factors enriched at nascent DNA molecules. Lopez-Contreras AJ et al., 2013 Apr 25, Cell RepRead more
- H3K9 methyltransferase G9a negatively regulates UHRF1 transcription during leukemia cell differentiation. Kim KB et al., 2015 Apr 20, Nucleic Acids ResRead more
- Transcriptional progression during meiotic prophase I reveals sex-specific features and X chromosome dynamics in human fetal female germline. Fan X et al., 2021 Sep, PLoS GenetRead more
- UHRF1 promotes androgen receptor-regulated CDC6 transcription and anti-androgen receptor drug resistance in prostate cancer through KDM4C-Mediated chromatin modifications. Gao Y et al., 2021 Nov 1, Cancer LettRead more