CVN417

MedChem Express

CVN417 [2919851-73-1]

14

Research Use Only

C18H23ClN4O2

362.85

CVN417 is an orally active alpha6 subunit-containing nAChR antagonist, modulating phasic dopaminergic neurotransmission in an impulse-dependent manner. CVN417 inhibits Ca(2+) effluents mediated by nAChR subunits with IC50s of 0.086 microM (alpha6), 2.56 microM (alpha3) and 0.657 microM (alpha4), respectively. CVN417 attenuates resting tremor in Rodent models, displays the potential to improve movement dysfunction, in conditions such as Parkinsons disease[1].

ClC1=C(C=CC(OC)=C1)C2=CC(C(N[C@@H]3CN(CCC3)C)=O)=NN2C

12131703