CW8001

MedChem Express

CW8001

999

Research Use Only

C12H8F3N5O2

311.22

CW8001 is a covalent XPO1 (Exportin-1) inhibitor with an EC50 value of 1 nM for inhibiting T cell activation. CW8001 prevents nuclear localization of NFAT transcription factors, suppressing expression of inflammatory cytokines like IL-2. CW8001 is promising for research of T cell-driven immune diseases such as graft-versus-host disease (GVHD)[1].

O=C1C(C)=CC(N1NC2=NC(C(F)(F)F)=NN3C2=CC=C3)=O

12352200