CX-5461

MedChem Express

CX-5461 [1138549-36-6]

5

1138549-36-6

Research Use Only

99.49

C27H27N7O2S

513.61

CX-5461 is a potent and oral rRNA synthesis inhibitor. It inhibits RNA polymerase I-driven transcription of rRNA with IC50s of 142, 113, and 54 nM in HCT-116, A375, and MIA PaCa-2 cells, respectively[1].

CC1=NC=C(CNC(C2=C3N(C4=NC(N5CCN(CCC5)C)=CC=C4C2=O)C6=C(S3)C=CC=C6)=O)N=C1

-20°C,2°C to 8°C

12352200