CX4338 [41609-06-7]
HY-119234
CAS Number41609-06-7
Product group Chemicals
Molecular Weight364.50
Overview
- SupplierMedChem Express
- Product NameCX4338 [41609-06-7]
- Delivery Days Customer9
- CAS Number41609-06-7
- CertificationResearch Use Only
- Molecular FormulaC22H24N2OS
- Molecular Weight364.50
- Scientific DescriptionCX4338 is a CXCL8-mediated chemokine inhibitor with the activity of inhibiting CXCR2-mediated cell migration. CX4338 selectively inhibits CXCR2-mediated beta-arrestin-2 recruitment and receptor internalization while enhancing CXCR2-mediated MAPK activation. CX4338 also inhibited CXCL8-induced chemotaxis, showing efficacy in CXCR2-overexpressing cells and human neutrophils. In vivo, CX4338 significantly reduced LPS-induced neutrophil numbers in mouse bronchoalveolar lavage fluid. The mechanism of action of CX4338 is to selectively inhibit CXCR2-mediated beta-arrestin-2 activation, which is sufficient to inhibit CXCL8-mediated chemotaxis[1].
- SMILESO=C1CC(C)(CC(NCC2=CC=CC=C2)=C1C(NC3=CC=CC=C3)=S)C
- UNSPSC12352200
MSDS
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Product group Chemicals
CAS Number41609-06-7
Molecular Weight364.5 g/mol
- SizePrice
Product group Chemicals
CX4338ORB1703573
CAS Number41609-06-7
Estimated Purity98%
Molecular Weight364.51
- SizePrice