CXCR4 antagonist 5 [2304749-86-6]

MedChem Express

CXCR4 antagonist 5 [2304749-86-6]

10

2304749-86-6

Research Use Only

C21H30N6

366.50

CXCR4 antagonist 5 (compound 23) is a highly potent CXCR4 antagonist with an IC50 value of 8.8 nM. CXCR4 antagonist 5 can inhibit CXCL12-induced cytosolic calcium increase (IC50 = 0.02 nM) and inhibits CXCR4/CXLC12-mediated chemotaxis. CXCR4 antagonist 5 has good physicochemical properties and in vitro safety profiles, inhibiting CYP isozymes and hERG marginally or moderately[1].

CC1=NC(N2CCN(CC2)C)=CC(CN([C@@H]3C4=C(C=CC=N4)CCC3)C)=N1

12131703