CXCR6 peptide
GTX28388
Overview
- SupplierGeneTex
- Product NameCXCR6 peptide
- Delivery Days Customer9
- ApplicationsNeutralisation/Blocking
- CertificationResearch Use Only
- Concentration0.20 mg/ml
- ConjugateUnconjugated
- Scientific DescriptionHuman Immunodeficiency Virus (HIV) and Simian Immunodeficiency Virus (SIV) require coreceptors to enter and infect target cells. They are dependent upon an interaction between the viral envelope glycoprotein with T-cell antigen T4 (CD4) and a G protein coupled receptor (GPCR). HIV-1 infection relies upon interaction with a chemokine receptor, usually chemokine (C-C) receptor 5 (CCR5). During progression of the infection, the virus tends to rely upon chemokine (C-X-C) receptor 4 (CXCR4). SIV also utilizes CCR5 in the early stages of infection, but during progression it tends to rely on two orphan GPCRs named chemokine (C-X-C) receptor 6 (Bonzo) and G protein coupled receptor 15 (BOB/GRP15). Bonzo mRNA expression has been localized to lymphoid tissues and activated peripheral blood lymphocytes.
- Storage Instruction-20°C
- UNSPSC12352202