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Cyclin D1 antibody [N1C3]

GTX108624
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityCanine, Feline, Human, Rat
TargetCCND1
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Overview

  • Supplier
    GeneTex
  • Product Name
    Cyclin D1 antibody [N1C3]
  • Delivery Days Customer
    9
  • Antibody Specificity
    IP/MS validation was supported by references (PMID:30377392)
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IP: 1:100-1:500. ELISA: 1:1000-1:10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID595
  • Target name
    CCND1
  • Target description
    cyclin D1
  • Target synonyms
    B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL1; BCL-1 oncogene; D11S287E; G1/S-specific cyclin-D1; PRAD1; PRAD1 oncogene; U21B31
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP24385
  • Protein Name
    G1/S-specific cyclin-D1
  • Scientific Description
    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq]
  • Reactivity
    Canine, Feline, Human, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Synergistic Effect of Ginsenoside Rh2 Combines with Ionizing Radiation on CT26/luc Colon Carcinoma Cells and Tumor-Bearing Animal Model.
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  • Downregulation of KLF10 contributes to the regeneration of survived renal tubular cells in cisplatin-induced acute kidney injury via ZBTB7A-KLF10-PTEN axis.
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  • Hyperforin Elicits Cytostatic/Cytotoxic Activity in Human Melanoma Cell Lines, Inhibiting Pro-Survival NF-kappaB, STAT3, AP1 Transcription Factors and the Expression of Functional Proteins Involved in Mitochondrial and Cytosolic Metabolism.
    Read more
  • Modulation of POPDC1 Expression by Phenothiazine and Trifluoperazine Suppress Colon Cancer Growth and Migration.
    Read more
  • Semaphorin 6C Suppresses Proliferation of Pancreatic Cancer Cells via Inhibition of the AKT/GSK3/beta-Catenin/Cyclin D1 Pathway. Hung YH et al., 2022 Feb 26, Int J Mol Sci
    Read more
  • Carpaine Promotes Proliferation and Repair of H9c2 Cardiomyocytes after Oxidative Insults. Sudi S et al., 2022 Feb 15, Pharmaceuticals (Basel)
    Read more
  • Calcitriol Suppresses Warburg Effect and Cell Growth in Human Colorectal Cancer Cells. Huang CY et al., 2021 Sep 14, Life (Basel)
    Read more
  • Effects of orlistat combined with enzalutamide and castration through inhibition of fatty acid synthase in a PC3 tumor-bearing mouse model. Tyan YS et al., 2021 May 28, Biosci Rep
    Read more
  • Dehydroxyhispolon Methyl Ether, A Hispolon Derivative, Inhibits WNT/beta-Catenin Signaling to Elicit Human Colorectal Carcinoma Cell Apoptosis. Fan HC et al., 2020 Nov 22, Int J Mol Sci
    Read more
  • Downregulation of circNRIP1 Suppresses the Paclitaxel Resistance of Ovarian Cancer via Regulating the miR-211-5p/HOXC8 Axis. Li M et al., 2020, Cancer Manag Res
    Read more