Cyclin D1 antibody [P2D11F11]
GTX72094
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Rat
TargetCCND1
Overview
- SupplierGeneTex
- Product NameCyclin D1 antibody [P2D11F11]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:200-1:500. IHC-P: 1:25-1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDP2D11F11
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID595
- Target nameCCND1
- Target descriptioncyclin D1
- Target synonymsB-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL1; BCL-1 oncogene; D11S287E; G1/S-specific cyclin-D1; PRAD1; PRAD1 oncogene; U21B31
- HostMouse
- IsotypeIgG2a
- Protein IDP24385
- Protein NameG1/S-specific cyclin-D1
- Scientific DescriptionThe protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]
- ReactivityHuman, Rat
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Modulation of extracellular signal-related kinase, cyclin D1, glial fibrillary acidic protein, and vimentin expression in estradiol-pretreated astrocyte cultures treated with competence and progression growth factors. Bramanti V et al., 2015 Sep, J Neurosci ResRead more