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Cyclin D1 antibody [P2D11F11]

Research Use Only
GTX72094
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Rat
TargetCCND1
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Overview

  • Supplier
    GeneTex
  • Product Name
    Cyclin D1 antibody [P2D11F11]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:200-1:500. IHC-P: 1:25-1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    P2D11F11
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID595
  • Target name
    CCND1
  • Target description
    cyclin D1
  • Target synonyms
    B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL1; BCL-1 oncogene; D11S287E; G1/S-specific cyclin-D1; PRAD1; PRAD1 oncogene; U21B31
  • Host
    Mouse
  • Isotype
    IgG2a
  • Protein IDP24385
  • Protein Name
    G1/S-specific cyclin-D1
  • Scientific Description
    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]
  • Reactivity
    Human, Rat
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Modulation of extracellular signal-related kinase, cyclin D1, glial fibrillary acidic protein, and vimentin expression in estradiol-pretreated astrocyte cultures treated with competence and progression growth factors. Bramanti V et al., 2015 Sep, J Neurosci Res
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