Cyclo(L-Pro-L-Val) [2854-40-2]

TargetMol Chemicals

Cyclo(L-Pro-L-Val) [2854-40-2]

10

2854-40-2

Chemical

Research Use Only

Cyclo(L-Pro-L-Val)

98.18%

C10H16N2O2

196.25

Cyclo(L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses anti-inflammatory activity and virulence activity against phytopathogenic microorganisms (e.g., R. fascians LMG 3605) and inhibits Gram-positive plant pathogens.Cyclo(L-Pro-L-Val) significantly inhibited IKKalpha phosphorylation and IkappaBalpha and NF-kappaB activation as well as iNOS and COX-2 activation in a concentration Cyclo(L-Pro-L-Val) significantly inhibited the phosphorylation of IKKalpha, IKKbeta, IkappaBalpha, and NF-kappaB, as well as the activation of iNOS and COX-2 in a concentration-dependent manner, and is a potential therapeutic agent for the treatment of inflammation-related diseases.

3 years

CC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C1=O

-20°C

12352200