Cyclopentenylcytosine

MedChem Express

Cyclopentenylcytosine [90597-22-1]

5

90597-22-1

Research Use Only

99.76

C10H13N3O4

239.23

Cyclopentenylcytosine (CPC) is a nucleoside analog that reduces the levels of cytidine triphosphate (CTP) and deoxycytidine triphosphate (dCTP) in leukemic cells by inhibiting CTP synthetase. Cyclopentenylcytosine also promotes the phosphorylation of 1-beta-D-arabinorubosylmannosylcytidine (araC) and its DNA intercalation activity. Cyclopentenylcytosine induces apoptosis and necrosis in the human T lymphocyte line MOLT-3 in a concentration (50-300 nM) and time (8-16 h) dependent manner. Co-treatment of cyclopentenylcytosine with araC enhances the effects of induction of apoptosis and necrosis, as well as its cytotoxicity in T lymphoblasts [1] .

O[C@H]1[C@H](N2C(N=C(N)C=C2)=O)C=C(CO)[C@H]1O

-20°C,2°C to 8°C

12352200