Cyclosporine A

AbMole BioScience

Cyclosporine A

9

59865-13-3

Chemical

Research Use Only

1

C62H111N11O12

1202.61

Cyclosporin A is an immunosuppressant that binds to cyclophilin and inhibits calcineurin with an IC50 of 7 nM. cyclosporin A [CsA] binds to the cyclophilin 18 (Cyp18)-CsA complex. the Cyp18-CsA complex recruits calcium-regulated neurophosphatase (CaN), leading to the blocking of cytokine gene transcription in activated T cells. CsA is a highly specific inhibitor of T-cell activation.

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2-8°C, dry, sealed, protect from light

12352200