CYH33 methanesulfonate [1494684-33-1]

TargetMol Chemicals

CYH33 methanesulfonate [1494684-33-1]

999

1494684-33-1

Research Use Only

CYH33 methanesulfonate

C25H33F3N8O8S2

694.7

CYH33 methanesulfonate is a highly selective and orally active inhibitor of PI3Kalpha, with IC50 values of 5.9 nM, 598 nM, 78.7 nM, and 225 nM against the alpha, beta, delta, and gamma isoforms, respectively. This compound effectively inhibits the phosphorylation of Akt and ERK, leading to a significant G1 phase arrest in breast cancer cells and non-small cell lung cancer (NSCLC) cells. Additionally, CYH33 methanesulfonate demonstrates potent activity against solid tumors.

3 years

CS(O)(=O)=O.COC(=O)Nc1cc(c(cn1)-c1nc(N2CCOCC2)c2cc(CN3CCN(CC3)S(C)(=O)=O)cn2n1)C(F)(F)F

-20°C

12352200