Cynaropicrin

MedChem Express

Cynaropicrin [35730-78-0]

10

35730-78-0

Research Use Only

99.79

C19H22O6

346.37

Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-alpha) release with IC50s of 8.24 and 3.18 microM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-kappaB signaling.

C=C([C@H]1O)[C@]([C@@]2([H])C1)([H])[C@](OC3=O)([H])[C@@](C3=C)([H])[C@@H](OC(C(CO)=C)=O)CC2=C

-20°C

12352200