Cynomolgus EPHB2 Protein (EPH-CM102)

KACTUS

Cynomolgus EPHB2 Protein (EPH-CM102)

9

Lyophilized

EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression. EPHB2 promotes endothelial-mesenchymal transition (EMT) and elicits associated pathologic characteristics of glioblastoma multiforme (GBM) such as invasion and migration. EPHB2 is epigenetically overexpressed in hypoxia, a condition highly prevalent in malignancy. Furthermore, HIF-2alpha is required for EPHB2 stabilization by hypoxia.

-20°C or -80°C,-80°C

12352204