Cynomolgus / Rhesus macaque CTLA-4 Protein, His Tag (MALS verified)

ACRObiosystems

Cynomolgus / Rhesus macaque CTLA-4 Protein, His Tag (MALS verified)

4

Immune Checkpoint Proteins

Research Use Only

95%

Powder

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.1 kDa. The protein migrates as 19-24 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Description: CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Cynomolgus / Rhesus macaque CTLA-4, His Tag (CT4-C5227) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Ser 160 (Accession # G7PL88-1). In the region Ala 37 - Ser 160, the AA sequence of Cynomolgus and Rhesus macaque CTLA-4 are homolog

-20℃

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