CYP2E1-IN-1 [38205-55-9]

MedChem Express

CYP2E1-IN-1 [38205-55-9]

5

38205-55-9

Research Use Only

99.95

C6H7NOS

141.19

CYP2E1-IN-1 (Compound 10) is an orally active cytochrome P450 2E1 (CYP2E1) inhibitor with a Kd of 7.02 microM, an IC50 of 1.64 microM, and a Ki of 0.897 microM. CYP2E1-IN-1 activates the Nrf2/HO-1 signaling pathway and inhibits ROS production, thereby alleviating pancreatic injury. CYP2E1-IN-1 has significant anti-inflammatory and antioxidant activities and can effectively reduce inflammation and oxidative stress in severe acute pancreatitis (SAP). CYP2E1-IN-1 can be used in the study of SAP and other inflammatory-related diseases[1].

CC(C1=C(N=CS1)C)=O

RT

12352200