Cytarabine 5-monophosphate [7075-11-8]

MedChem Express

Cytarabine 5-monophosphate [7075-11-8]

5

7075-11-8

Research Use Only

98.04

h302-h315-h319-h335,p261-p264-p270-p271-p280-p302+p352-p304+p340-p305+p351+p338-p330-p362+p364-p403+p233-p405-p501

C9H14N3O8P

323.20

Cytarabine 5-monophosphate is a metabolite of the nucleoside analog Cytarabine (HY-13605), catalyzed by deoxycytidine kinase. Cytarabine 5-monophosphate is incorporated into DNA by DNA polymerase alpha, which reduces the rate of DNA synthesis. At a concentration of 15 mM, Cytarabine 5-monophosphate inhibits nuclear and mitochondrial DNA replication in Saccharomyces cerevisiae (S. cerevisiae). Additionally, Cytarabine 5-monophosphate (3.5-75.1 mg/kg) improves survival in leukemia mice (L1210 mice). Cytarabine 5-monophosphate can be used in cancer research[1].

O[C@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N2C(N=C(N)C=C2)=O

-20°C

12352200