Bio-Connect

CZS-241

HY-149912
MedChem Express
Molecular Weight551.98
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    CZS-241 [3016297-55-2]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Molecular Formula
    C26H24ClF2N9O
  • Molecular Weight
    551.98
  • Scientific Description
    CZS-241 is an orally active and selective inhibitor of Polo-like Kinase (PLK) 4 (IC50=2.6 nM). CZS-241 inhibits TRKA with an IC50 value of 2.74 microM. CZS-241 induces apoptosis and arrests cell cycle at S/G2 phase. CZS-241 shows highly potent antiproliferative activity against leukemia cell lines, and exhibits safety against normal cell lines[1].
  • SMILES
    FC1=CC=C(C=C1NC(C2=C(C=CC(CNC3=NC4=C(C(NC5=NNC(C)=C5)=N3)C=NN4C(C)C)=C2)Cl)=O)F
  • UNSPSC
    12131703