CZS-241
HY-149912
Overview
- SupplierMedChem Express
- Product NameCZS-241 [3016297-55-2]
- Delivery Days Customer10
- CertificationResearch Use Only
- Molecular FormulaC26H24ClF2N9O
- Molecular Weight551.98
- Scientific DescriptionCZS-241 is an orally active and selective inhibitor of Polo-like Kinase (PLK) 4 (IC50=2.6 nM). CZS-241 inhibits TRKA with an IC50 value of 2.74 microM. CZS-241 induces apoptosis and arrests cell cycle at S/G2 phase. CZS-241 shows highly potent antiproliferative activity against leukemia cell lines, and exhibits safety against normal cell lines[1].
- SMILESFC1=CC=C(C=C1NC(C2=C(C=CC(CNC3=NC4=C(C(NC5=NNC(C)=C5)=N3)C=NN4C(C)C)=C2)Cl)=O)F
- UNSPSC12131703