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ProductsBack/D-alpha-Hydroxyglutaric acid [13095-47-1]

D-alpha-Hydroxyglutaric acid [13095-47-1]

HY-113038
MedChem Express
CAS Number13095-47-1
Product group Chemicals
Estimated Purity98.0
Molecular Weight148.11
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Overview

  • Supplier
    MedChem Express
  • Product Name
    D-alpha-Hydroxyglutaric acid [13095-47-1]
  • Delivery Days Customer
    10
  • CAS Number
    13095-47-1
  • Certification
    Research Use Only
  • Estimated Purity
    98.0
  • Molecular Formula
    C5H8O5
  • Molecular Weight
    148.11
  • Scientific Description
    D-alpha-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-alpha-Hydroxyglutaric acid is a weak competitive antagonist of alpha-ketoglutarate (alpha-KG) and inhibits multiple alpha-KG-dependent dioxygenases with a Ki of 10.87 mM. D-alpha-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-alpha-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling[1][2][3][4][5].
  • SMILES
    O=C(O)[C@H](O)CCC(O)=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

MSDS

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