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D-alpha-Hydroxyglutaric acid (disodium)

HY-100542
MedChem Express
CAS Number103404-90-6
DownloadMSDS
Product group Chemicals
Estimated Purity98.0
Molecular Weight192.08
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Overview

  • Supplier
    MedChem Express
  • Product Name
    D-alpha-Hydroxyglutaric acid (disodium) [103404-90-6]
  • Delivery Days Customer
    9
  • CAS Number
    103404-90-6
  • Estimated Purity
    98.0
  • Molecular Formula
    C5H6Na2O5
  • Molecular Weight
    192.08
  • Scientific Description
    D-alpha-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-alpha-Hydroxyglutaric acid disodium is a weak competitive antagonist of alpha-ketoglutarate (alpha-KG) and inhibits multiple alpha-KG-dependent dioxygenases with a K i of 10.87 mM. D-alpha-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-alpha-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling [1] [2] [3] [4] [5] .
  • SMILES
    O=C(O[Na])[C@H](O)CCC(O[Na])=O
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200