[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P [96736-12-8]
HY-103544
Product group Proteins / Signaling Molecules
Overview
- SupplierMedChem Express
- Product Name[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P [96736-12-8]
- Delivery Days Customer14
- CAS Number96736-12-8
- CertificationResearch Use Only
- Estimated Purity98.48
- Scientific Description[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P, a Substance P derivative, is a biased agonist toward neuropeptide and chemokine receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P activates G12. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P binds to IL-8 and GRP receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P inhibits ERK-2 activation, activates JNK activity. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P stimulates an increase in neutrophil migration and Ca2+ mobilization. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is also a bombesin antagonist, and inhibits the growth of small cell lung cancer[1][2][3]
- Storage Instruction-20°C,-80°C
- UNSPSC41116100