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ProductsBack/[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

HY-103544
MedChem Express
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Product group Proteins / Signaling Molecules
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Overview

  • Supplier
    MedChem Express
  • Product Name
    [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P [96736-12-8]
  • Delivery Days Customer
    14
  • Certification
    Research Use Only
  • Scientific Description
    [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P, a Substance P derivative, is a biased agonist toward neuropeptide and chemokine receptors. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P activates G12 . [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P binds to IL-8 and GRP receptors . [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P inhibits ERK-2 activation, activates JNK activity. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P stimulates an increase in neutrophil migration and Ca 2+ mobilization. [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is also a bombesin antagonist, and inhibits the growth of small cell lung cancer [1] [2] [3]
  • UNSPSC
    12352202