D-erythro-Dihydrosphingosine [Sphinganine] [764-22-7]

AdipoGen Life Sciences

D-erythro-Dihydrosphingosine [Sphinganine]

10

764-22-7

Research Use Only

Chemical. CAS: 764-22-7. Formula: C18H39NO2. MW: 301.5. Soluble in DMSO (20mg/ml) or ethanol (20mg/ml). The metabolite sphinganine activates the CD4+ regulatory T (Treg) cells, which accumulate in the tumor microenvironment (TME) and suppress the immune system. Sphinganine activates the Treg cells by physically interacting with the transcription factor c-Fos, and consequently increasing Treg cell proliferation. Sphinganine is a precursor of ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate. Sphinganine is an inhibitor of protein kinase C and phospholipases A2 and D. Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins, as well as in some cancers. Sphinganine has been proposed to function as a c-Src kinase inhibitor in a drug-induced cancer cell model. - The metabolite sphinganine activates the CD4+ regulatory T (Treg) cells, which accumulate in the tumor microenvironment (TME) and suppress the immune system. Sphinganine activates the Treg cells by physically interacting with the transcription factor c-Fos, and consequently increasing Treg cell proliferation. Sphinganine is a precursor of ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate. Sphinganine is an inhibitor of protein kinase C and phospholipases A2 and D. Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins, as well as in some cancers. Sphinganine has been proposed to function as a c-Src kinase inhibitor in a drug-induced cancer cell model.

-20°C,2°C to 8°C

12352200