D927 [2253733-37-6]
HY-128574
CAS Number2253733-37-6
Product group Chemicals
Estimated Purity99.46
Molecular Weight452.50
Overview
- SupplierMedChem Express
- Product NameD927 [2253733-37-6]
- Delivery Days Customer10
- CAS Number2253733-37-6
- CertificationResearch Use Only
- Estimated Purity99.46
- Molecular FormulaC23H21FN4O3S
- Molecular Weight452.50
- Scientific DescriptionD927 (DS11252927) is an orally active glucose transporter type 4 (GLUT4) translocation activator with an EC50 of 0.14 microM. D927 enhances the binding affinity of PI3Kalpha catalytic subunit p110alpha to canonical RAS proteins (KRAS4A, KRAS4B) and RRAS, RRAS2, MRAS. D927 activates the PI3Kalpha-AKT pathway (increasing phosphorylation of AKT, p70S6 kinase) without affecting the RAF-ERK1/2 pathway. D927 improves hyperglycemia in type 1 and type 2 diabetes mice model. D927 can be used for the study of glucose homeostasis disorders and diabetes[1][2].
- SMILESCOCCOC1=CC=CC=C1C2=C(SC=C3)C3=C(NC4=CC=C(CC(N)=O)C=C4F)N=N2
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200
MSDS
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GLUT4 activator 1ORB1709589
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Product group Chemicals
CAS Number2253733-37-6
Molecular Weight452.5
- SizePrice