Dact2 antibody

GeneTex

Dact2 antibody

9

WB: 1 microg/mL. IHC-P: 2.5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

DACT2

dishevelled binding antagonist of beta catenin 2

bA503C24.7; C6orf116; dapper antagonist of catenin 2; dapper homolog 2; dapper homolog 2, antagonist of beta-catenin; dapper, antagonist of beta-catenin, homolog 2; DAPPER2; DPR2

Rabbit

IgG

Dapper homolog 2

The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus kidneys, and salivary gland. Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a b-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-b receptors. At least two isoforms of Dact2 are known to exist.

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203