DAD1 antibody

GeneTex

DAD1 antibody

9

WB: 0.5 - 2 microg/mL. ICC/IF: 10 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

DAD1

defender against cell death 1

OST2, dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1, DAD-1, oligosaccharyl transferase subunit DAD1, oligosaccharyltransferase 2 homolog, oligosaccharyltransferase subunit 2 (non-catalytic)

Rabbit

IgG

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

Defender of cell death 1 (DAD1) was initially discovered in BHK21 cells as a negative regulator of programmed cell death (1), a process important for normal organism development and tissue homeostasis (2). DAD1 was later shown to be a subunit of the mammalian oligosaccharyltransferase complex and is required for its function and structural integrity (3,4). Mice lacking DAD1 express abnormal N-linked glycoproteins and undergo increased apoptotic-associated embryonic death (5,6). Furthermore, overexpression of DAD1 mRNA is seen in some human hepatocellular carcinomas (7), indicating it may also play a role in carcinogenesis. It should be noted that DAD1 is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

-20°C or -80°C,2°C to 8°C

12352203