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DAG1 antibody

GTX105038
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetDAG1
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Overview

  • Supplier
    GeneTex
  • Product Name
    DAG1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.28 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID1605
  • Target name
    DAG1
  • Target description
    dystroglycan 1
  • Target synonyms
    156DAG; A3a; AGRNR; DAG; dystroglycan; dystroglycan 1 (dystrophin-associated glycoprotein 1); LGMDR16; MDDGA9; MDDGC7; MDDGC9
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ14118
  • Protein Name
    Dystroglycan
  • Scientific Description
    Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Absence of alpha- and beta-dystroglycan is associated with Walker-Warburg syndrome. Riemersma M et al., 2015 May 26, Neurology
    Read more
  • Disease mutations in CMP-sialic acid transporter SLC35A1 result in abnormal alpha-dystroglycan O-mannosylation, independent from sialic acid. Riemersma M et al., 2015 Apr 15, Hum Mol Genet
    Read more
  • Transcriptome profiling of granulosa and theca cells during dominant follicle development in the horse. Donadeu FX et al., 2014 Nov, Biol Reprod
    Read more
  • Virus entry. Lassa virus entry requires a trigger-induced receptor switch. Jae LT et al., 2014 Jun 27, Science
    Read more

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