Danicopan (ALXN2040)
M10145
CAS Number1903768-17-1
Product group Chemicals
Molecular Weight580.41
Overview
- SupplierAbMole BioScience
- Product NameDanicopan (ALXN2040)
- Delivery Days Customer9
- CAS Number1903768-17-1
- Category SupplierChemical
- CertificationResearch Use Only
- Molecular FormulaC26H23BrFN7O3
- Molecular Weight580.41
- Scientific DescriptionDanicopan (ALXN2040, ACH-4471, ACH-0144471) is a first-in-class, potent, selective, orally active inhibitor of complement factor D with a Kd value of 0.54 nM for human Factor D. Danicopan can Selectively inhibits key complement factor D in the alternative pathway, blocking C3 convertase production and inhibiting alternative pathway activity. It also prevents the deposition of C3b fragments on blood erythrocytes and inhibits erythrocyte catabolism and extravascular hemolysis.
- SMILESCC(=O)C1=N[N](CC(=O)N2CC(F)CC2C(=O)NC3=NC(=CC=C3)Br)C4=C1C=C(C=C4)C5=CN=C(C)N=C5
- UNSPSC12352200