Dantrolene

MedChem Express

Dantrolene [7261-97-4]

10

7261-97-4

Research Use Only

98.0

C14H10N4O5

314.257

Dantrolene is an orally active, non-competitive glutathione reductase inhibitor with a K i of 111.6 microM and an IC 50 of 52.3 microM. Dantrolene is also a calcium channel protein inhibitor. Dantrolene inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] .

O=C1NC(CN1/N=C/C2=CC=C(C3=CC=C([N+]([O-])=O)C=C3)O2)=O

-20°C,2°C to 8°C

12352200