Dantrolene (sodium) [14663-23-1]

MedChem Express

Dantrolene (sodium) [14663-23-1]

10

14663-23-1

Research Use Only

99.79

C14H9N4NaO5

336.23

Dantrolene sodium is an orally active, non-competitive glutathione reductase inhibitor with a Ki of 111.6 microM and an IC50 of 52.3 microM. Dantrolene sodium is also a calcium channel protein inhibitor. Dantrolene sodium inhibits the release of Ca2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene sodium offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties[1][2][3][4][5][6][7][8][9][10][11].

O=C([N-]1)N(/N=C/C2=CC=C(C3=CC=C([N+]([O-])=O)C=C3)O2)CC1=O.[Na+]

2°C to 8°C

12352200