Dantrolene (sodium hemiheptahydrate)

MedChem Express

Dantrolene (sodium hemiheptahydrate) [24868-20-0]

9

24868-20-0

Research Use Only

99.79

C14H10N4O5.7/2H2O.Na

399.31

Dantrolene sodium hemiheptahydrate is an orally active, non-competitive glutathione reductase inhibitor with a K i of 111.6 microM and an IC 50 of 52.3 microM. Dantrolene sodium hemiheptahydrate is also a calcium channel protein inhibitor. Dantrolene sodium hemiheptahydrate inhibits the release of Ca 2+ from RyR1 and RyR3, which can be beneficial in a variety of pathologies caused by disruptions in calcium homeostasis (e.g., stroke, ischemia/reperfusion injury, and neurodegenerative diseases). Dantrolene sodium hemiheptahydrate offers relief of muscle spasms, malignant hyperthermia, and antitoxic, antipyretic, and anti-inflammatory properties [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] .

O=C1N([Na])C(CN1/N=C/C2=CC=C(C3=CC=C([N+]([O-])=O)C=C3)O2)=O.[3.5H2O]

2°C to 8°C

12352200