DAP12 antibody

GeneTex

DAP12 antibody

9

DAP12 in transfected cell lysate

For WB: Use at a dilution of 1:2,000. Optimal dilutions/concentrations should be determined by the end user.

Western Blot

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

TYROBP

transmembrane immune signaling adaptor TYROBP

DAP12; DNAX adaptor protein 12; DNAX-activation protein 12; KARAP; KAR-associated protein; killer-activating receptor-associated protein; PLOSL; PLOSL1; polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy; TYRO protein tyrosine kinase binding protein; TYRO protein tyrosine kinase-binding protein

Rabbit

IgG

TYRO protein tyrosine kinase-binding protein

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]

Human

-20°C or -80°C,2°C to 8°C

12352203