Daphnetin

MedChem Express

Daphnetin [486-35-1]

10

486-35-1

Research Use Only

99.86

C9H6O4

178.143

Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne , is a potent, oral active protein kinase inhibitor, with IC 50 s of 7.67 microM, 9.33 microM and 25.01 microM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-alpha, IL-1?, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research [1] [2] [3] [4] .

O=C1C=CC2=CC=C(O)C(O)=C2O1

-20°C,2°C to 8°C

12352200