DAPT

MedChem Express

DAPT [208255-80-5]

5

208255-80-5

Research Use Only

99.97

C23H26F2N2O4

432.46

DAPT (GSI-IX) is a potent and orally active gamma-secretase inhibitor with IC 50 s of 115 nM and 200 nM for total amyloid-beta (Abeta) and Abeta 42 , respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis . DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment [1] [2] .

FC1=CC(F)=CC(CC(N[C@H](C(N[C@H](C(OC(C)(C)C)=O)C2=CC=CC=C2)=O)C)=O)=C1

-20°C,2°C to 8°C

12352200