Dasatinib

MedChem Express

Dasatinib [302962-49-8]

10

302962-49-8

Research Use Only

99.85

C22H26ClN7O2S

488.017

Dasatinib (BMS-354825) is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The K i s are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib inhibits Bcr-Abl and Src with IC 50 s of [1] . Dasatinib also induces apoptosis and autophagy .

O=C(C1=CN=C(S1)NC2=NC(C)=NC(N3CCN(CC3)CCO)=C2)NC4=C(C=CC=C4Cl)C

-20°C,2°C to 8°C

12352200