Dasatinib-d4

MedChem Express

Dasatinib-d4

5

Research Use Only

C22H22D4ClN7O2S

492.03

Dasatinib-d4 (BMS-354825-d4) is deuterium labeled Dasatinib. Dasatinib (BMS-354825) is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib inhibits Bcr-Abl and Src with IC50s of [1][2]. Dasatinib also induces apoptosis and autophagy.

OC([2H])([2H])C([2H])([2H])N(CC1)CCN1C2=NC(C)=NC(NC3=NC=C(C(NC4=C(C=CC=C4Cl)C)=O)S3)=C2

12352200