DB0614

Biorbyt

DB0614

10

Research Use Only

98.00%

C41H42N8O7S2

822.95

DB0614 (Example 21) is a bifunctional compound designed for the targeted degradation of kinases, effectively breaking down AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK, LCK, LIMK2, MAP3KH, MAPK8, MAPK9, NEK9, PLK4, PTK2B, SIK2, STK17A, STK17B, ULK1, ULK3, and WEE1. This compound has potential applications in research on diseases or disorders caused by aberrant kinase activity [1].

CS(=O)(=O)Nc1cccc(c1)-c1csc2cnc(Nc3ccc(cc3)N3CCN(CCCCCOc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)nc12

-20°C

12352200