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DB1976 (dihydrochloride) [2369663-93-2]

HY-135797A
MedChem Express
CAS Number2369663-93-2
Product group Chemicals
Estimated Purity98.0
Molecular Weight520.28
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Overview

  • Supplier
    MedChem Express
  • Product Name
    DB1976 (dihydrochloride) [2369663-93-2]
  • Delivery Days Customer
    9
  • CAS Number
    2369663-93-2
  • Certification
    Research Use Only
  • Estimated Purity
    98.0
  • Molecular Formula
    C20H18Cl2N8Se
  • Molecular Weight
    520.28
  • Scientific Description
    DB1976 dihydrochloride is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 dihydrochloride potently inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-lambdaB affinity, KD of 12 nM) in vitro. DB1976 dihydrochloride has apoptosis-inducing effect[1][2][3].
  • SMILES
    N=C(C1=CC=C2N=C(C3=CC=C(C4=NC5=CC=C(C(N)=N)C=C5N4)[Se]3)NC2=C1)N.[H]Cl.[H]Cl
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200