FACS analysis of human DC-SIGN transfected K562 cells using GTX42261 DC-SIGN antibody [MR-1] (Low endotoxin, azide free).
DC-SIGN antibody [MR-1] (Low endotoxin, azide free)
GTX42261
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry, Neutralisation/Blocking
Product group Antibodies
ReactivityHuman
TargetCD209
Overview
- SupplierGeneTex
- Product NameDC-SIGN antibody [MR-1] (Low endotoxin, azide free)
- Delivery Days Customer9
- Antibody SpecificityThis antibody recognizes human DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN).
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDMR-1
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID30835
- Target nameCD209
- Target descriptionCD209 molecule
- Target synonymsCD209 antigen; CDSIGN; CLEC4L; C-type lectin domain family 4 member L; DC-SIGN; DC-SIGN1; dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin; hDC-SIGN; HIV gpl20-binding protein
- HostMouse
- IsotypeIgG1
- Scientific DescriptionThis gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203
References
- Dendritic cells respond to nasopharygeal carcinoma cells through annexin A2-recognizing DC-SIGN. Chao PZ et al., 2015 Jan 1, OncotargetRead more