DCG066 [494786-13-9]

MedChem Express

DCG066 [494786-13-9]

14

494786-13-9

Research Use Only

99.78

C30H31F6N3O2

579.58

DCG066 is an inhibitor of lysine methyltransferase G9a. DCG066 can bind directly to G9a and inhibit methyltransferase activity in vitro. DCG066 decreases di-methylation levels of histone H3 lysine 9 (H3K9Me2), inhibits cell proliferation and induces cell apoptosis. DCG066 displays low cytotoxicity in leukemia cell lines with high levels of G9a expression, including K562[1].

O=C(N(C)C)NC1=CC=C(C=C1)CN2CCC(CC2)C(O)(C3=CC=C(C=C3)C(F)(F)F)C4=CC=C(C=C4)C(F)(F)F

-20°C,2°C to 8°C

12352200