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DCLK1-IN-1 [2222635-15-4]

DCLK1-IN-1 [2222635-15-4]

T8418
TargetMol Chemicals
CAS Number2222635-15-4
DownloadMSDS
Product group Chemicals
Estimated Purity98.55%
Molecular Weight527.54
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    DCLK1-IN-1 [2222635-15-4]
  • Delivery Days Customer
    9
  • CAS Number
    2222635-15-4
  • Category Supplier
    Chemical
  • Chemical Name
    DCLK1-IN-1
  • Estimated Purity
    98.55%
  • Molecular Formula
    C26H28F3N7O2
  • Molecular Weight
    527.54
  • Scientific Description
    DCLK1-IN-1 is a selective, in vivo compatible chemical probe of the kinase domain of doublecortin-like kinase 1 (DCLK1) and a highly selective DCLK1/2 inhibitor with IC50 values of 9.5/57.2 nM (DCLK1) and 31/103 nM (DCLK2) by binding and kinase assays, respectively. It has low toxicity and is used to study DCLK1 biology and determine its role in cancer.
  • Shelf life instruction
    3 years
  • SMILES
    COc1cc(ccc1Nc1ncc2N(CC(F)(F)F)C(=O)c3ccccc3N(C)c2n1)N1CCN(C)CC1
  • Storage Instruction
    -20°C
  • UNSPSC
    51202000

References

  • Inhibition of DCLK1 with DCLK1-IN-1 Suppresses Renal Cell Carcinoma Invasion and Stemness and Promotes Cytotoxic T-Cell-Mediated Anti-Tumor Immunity. Ding L et al., 2021 Nov 16, Cancers (Basel)
    Read more