DCP-LA(FR 236924)

Biorbyt

DCP-LA(FR 236924)

10

Research Use Only

DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCepsilon. DCP-LA activates Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis.

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