Bio-Connect

DDB1 antibody

GTX100130
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetDDB1
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Overview

  • Supplier
    GeneTex
  • Product Name
    DDB1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:500-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.34 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID1642
  • Target name
    DDB1
  • Target description
    damage specific DNA binding protein 1
  • Target synonyms
    damage-specific DNA binding protein 1, 127kDa; DDB p127 subunit; DDBA; DNA damage-binding protein 1; DNA damage-binding protein a; HBV X-associated protein 1; UV-damaged DNA-binding factor; UV-damaged DNA-binding protein 1; UV-DDB 1; UV-DDB1; WHIKERS; XAP1; XAP-1; xeroderma pigmentosum group E-complementing protein; XPCE; XPE; XPE-BF; XPE-binding factor
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ16531
  • Protein Name
    DNA damage-binding protein 1
  • Scientific Description
    This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • O-GlcNAc has crosstalk with ADP-ribosylation via PARG.
    Read more
  • Zinc-finger protein CXXC5 promotes breast carcinogenesis by regulating the TSC1/mTOR signaling pathway.
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  • CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy. Fu SJ et al., 2020 May 26, Cells
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  • Regulation of liver receptor homologue-1 by DDB2 E3 ligase activity is critical for hepatic glucose metabolism. Lai TC et al., 2019 Mar 28, Sci Rep
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  • Human DNA Ligase I Interacts with and Is Targeted for Degradation by the DCAF7 Specificity Factor of the Cul4-DDB1 Ubiquitin Ligase Complex. Peng Z et al., 2016 Oct 14, J Biol Chem
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  • Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation. Li Q et al., 2015 Aug 28, J Biol Chem
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  • The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels. Chen YA et al., 2015 May 29, Sci Rep
    Read more
  • DDB2 association with PCNA is required for its degradation after UV-induced DNA damage. Cazzalini O et al., 2014, Cell Cycle
    Read more