DDO-5936

Biorbyt

DDO-5936 [2355377-13-6]

10

2355377-13-6

Research Use Only

C25H29N5O4S

495.59

DDO-5936 is a potent PPI inhibitor targeting Hsp90-Cdc37 protein-protein interaction (PPI) as Orally Active Inhibitors for the Treatment of Colorectal Cancer. DDO-5936 disrupted the Hsp90-Cdc37 PPI both in vitro and in vivo via binding to a previously unknown site on Hsp90 involving Glu47, one of the binding determinants for the Hsp90-Cdc37 PPI, leading to selective down-regulation of Hsp90 kinase clients in HCT116 cells. In addition, inhibition of Hsp90-Cdc37 complex formation by DDO-5936 resulted in a remarkable cyclin-dependent kinase 4 decrease and consequent inhibition of cell proliferation through Cdc37-dependent cell cycle arrest.

C1CCCN1C1N=C(C=CN=1)NC1=CC=C(C=C1)N(S(=O)(=O)C1C(=CC(=CC=1C)C)C)CC(=O)O

12352200