DDX11 Antibody

Cusabio

DDX11 Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

DDX11

DEAD/H-box helicase 11

ATP-dependent DNA helicase DDX11; CHL1; CHL1-like helicase homolog; CHL1-related helicase gene-1; CHL1-related protein 1; CHLR1; DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae); DEAD/H box protein 11; hCHLR1; keratinocyte growth factor-regulated gene 2 protein; KRG2; KRG-2; probable ATP-dependent DNA helicase DDX11; probable ATP-dependent RNA helicase DDX11; WABS

Rabbit

IgG

ATP-dependent DNA helicase DDX11

DNA helicase involved in cellular proliferation. Possesses DNA-dependent ATPase and helicase activities. This helicase translocates on single-stranded DNA in the 5 to 3 direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5-single-stranded region for helicase loading, since flush-ended duplex structures do not support unwinding. The helicase activity is capable of displacing duplex regions up to 100 bp, which can be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC (replication factor C) complex activities. Stimulates the flap endonuclease activity of FEN1. Required for normal sister chromatid cohesion. Required for recruitment of bovine papillomavirus type 1 regulatory protein E2 to mitotic chrmosomes and for viral genome maintenance. Required for maintaining the chromosome segregation and is essential for embryonic development and the prevention of aneuploidy. May function during either S, G2, or M phase of the cell cycle. Binds to both single- and double-stranded DNA.

-20°C or -80°C

12352203