DDX42 Antibody

Cusabio

DDX42 Antibody

20

ImmunoFluorescence, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

DDX42

DEAD-box helicase 42

ATP-dependent RNA helicase DDX42; DDX42P; DEAD (Asp-Glu-Ala-Asp) box helicase 42; DEAD (Asp-Glu-Ala-Asp) box polypeptide 42; RHELP; RNAHP; SF3b DEAD box protein; SF3b125; SF3B8; splicing factor 3b, subunit 8; splicing factor 3B-associated 125 kDa protein

Rabbit

IgG

ATP-dependent RNA helicase DDX42

ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm.

-20°C or -80°C

12352203